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Table 2 Comparison of breast cancer diagnostic performance of each model with radiologists in different BI-RADS modes

From: Head-to-head comparison of perfluorobutane contrast-enhanced US and multiparametric MRI for breast cancer: a prospective, multicenter study

 

BI-RADS (3 vs. 4a+)

BI-RADS (3, 4a vs. 4b+)

BI-RADS (3, 4a, 4b vs. 4c+)

Se%

P value

Sp%

P value

Se%

P value

Sp%

P value

Se%

P value

Sp%

P value

PFB-CEUS

 On-sitea

97.4 (112/115)

 

56.3 (40/71)

 

93.9 (108/115)

 

78.9 (56/71)

 

78.3 (90/115)

 

91.5 (65/71)

 

(92.6, 99.5)

 

(44.0, 68.1)

 

(87.9, 97.5)

 

(67.6, 87.7)

 

(69.6, 85.4)

 

(82.5, 96.8)

 

 Reviewersb

94.8 (109/115)

 

36.6 (26/71)

 

86.1 (99/115)

 

70.4 (50/71)

 

78.3 (90/115)

 

78.9 (56/71)

 

(89.0, 98.1)

 

(25.5, 48.9)

 

(78.4, 91.8)

 

(58.4, 80.7)

 

(69.6, 85.4)

 

(67.6, 87.7)

 

 CEUS model

NA

–c

NA

–c

97.4 (112/115)

0.344c

36.6 (26/71)

< 0.001c

88.7 (102/115)

0.029c

80.3 (57/71)

0.096c

 

–d

 

–d

(92.6, 99.5)

0.001d

(25.5, 48.9)

< 0.001d

(81.4, 93.8)

0.023d

(69.1, 88.8)

–d

 Hybrid model

100.0 (115/115)

–c

25.4 (18/71)

< 0.001c

100.0 (115/115)

–c

50.7 (36/71)

0.001c

90.4 (104/115)

0.004c

84.5 (60/71)

0.332c

(96.8, 100.0)

–d

(15.8, 37.1)

0.229d

(96.8,100.0)

–d

(38.6, 62.8)

0.009d

(83.5, 95.1)

0.004d

(74.0, 92.0)

0.454d

MP-MRI

 On-sitea

98.3 (113/115)

 

49.3 (35/71)

 

92.2 (106/115)

 

73.2 (52/71)

 

80.0 (92/115)

 

87.3 (62/71)

 

(93.9, 99.8)

 

(37.2, 61.4)

 

(85.7, 96.4)

 

(61.4, 83.1)

 

(71.5, 86.9)

 

(77.3, 94.0)

 

 Reviewersb

93.9 (108/115)

 

25.4 (18/71)

 

89.6 (103/115)

 

46.5 (33/71)

 

81.7 (94/115)

 

67.6 (48/71)

 

(87.9, 97.5)

 

(15.8, 37.1)

 

(82.5, 94.5)

 

(34.5, 58.7)

 

(73.5, 88.3)

 

(55.5, 78.2)

 

 MRI model

100.0 (115/115)

–e

11.3 (8/71)

< 0.001e

98.3 (113/115)

0.016e

40.8 (29/71)

< 0.001e

88.7 (102/115)

0.041e

80.3 (57/71)

0.332e

(96.8, 100.0)

–f

(5.0, 21.0)

0.041f

(93.9, 99.8)

0.006f

(29.3,53.2)

0.627f

(81.4, 93.8)

0.134f

(69.1, 88.8)

0.078f

 Hybrid model

100.0 (115/115)

–e

25.4 (18/71)

0.002e

100.0 (115/115)

–e

50.7 (36/71)

0.004e

90.4 (104/115)

0.017e

84.5 (60/71)

0.815e

(96.8, 100.0)

–f

(15.8, 37.1)

–f

(96.8, 100.0)

–f

(38.6, 62.8)

0.711f

(83.5, 95.1)

0.052f

(74.0, 92.0)

0.023f

  1. The model’s sensitivity was determined by setting the model’s specificity to match the on-site/reviewers’ specificity; the model’s specificity was determined by setting the model’s sensitivity to match the on-site/reviewers’ sensitivity. Se sensitivity, Sp specificity. NA means the PFB-CEUS model’s breast lesion diagnosis as BI-RADS 3 grade is absent. Data in parentheses are the numerator and denominator and the 95% confidence intervals
  2. a25 radiologists who performed PFB-CEUS and 27 radiologists who performed MP-MRI
  3. b3 radiologists who reviewed the stored PFB-CEUS and 3 radiologists who reviewed the stored MP-MRI images
  4. cP value for comparisons with the diagnostic results of PFB-CEUS radiologists on-site
  5. dP value for comparisons with the diagnostic results of the PFB-CEUS reviewers
  6. eP value for comparisons with the diagnostic results of MP-MRI radiologists on-site
  7. fP value for comparisons with diagnostic results of MP-MRI reviewers
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Breast Cancer Research

ISSN: 1465-542X

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