Fig. 6

A benign breast lesion was diagnosed as a cancer by PFB-CEUS and MP-MRI but was diagnosed as a benign lesion by the hybrid model. This is a 50-year-old woman with ductal hyperplasia by pathological diagnosis. a At the 12th second, PFB-CEUS had arrived at the peak intensity. The lesion on PFB-CEUS was the same size as that on gray ultrasound. b TIC of PFB-CEUS shows a 14 s fall time of the lesion. c DWI shows a high signal lesion with an ADC value of 1.2 * 10^–3 mm²/s. d DCE-MRI shows the patients with a marked BPE and a lesion with a circumscribed margin. e PFB-CEUS Nomogram shows that this case had a 36% MP at the https://ceus.shinyapps.io/PFB-CEUS/link. f MP-MRI Nomogram shows that this case had a 40% MP at the https://ceus.shinyapps.io/MP-MRI/link. g Hybrid Nomogram shows that this case had a 14% MP at the https://ceus.shinyapps.io/hybrid/link. MP-MRI multiparametric magnetic resonance imaging, PFB-CEUS perfluorobutane contrast-enhanced ultrasound, DWI diffusion weighted imaging, ADC apparent diffusion coefficient, DCE-MRI dynamic contrast-enhanced magnetic resonance imaging, BPE background parenchymal enhancement, TIC time–intensity curve, FT fall time, MP malignant probability