Fig. 5
A breast cancer was diagnosed by PFB-CEUS as a malignant lesion but was diagnosed as a benign lesion by MP-MRI. This is a 50-year-old woman with an invasive carcinoma by pathological diagnosis. a At the 8th second, PFB-CEUS had arrived at the peak intensity. The lesion on PFB-CEUS was the same size as that on gray ultrasound. b TIC of PFB-CEUS shows a 6.6 s fall time of the lesion. c DWI shows a high signal lesion with an ADC value of 1.6 * 10–3 mm2/s. d DCE-MRI shows the patients with a marked BPE and a lesion with a noncircumscribed margin. e PFB-CEUS Nomogram shows that this case had an 82% MP at the https://ceus.shinyapps.io/PFB-CEUS/link. f MP-MRI Nomogram shows that this case had a 38% MP at the https://ceus.shinyapps.io/MP-MRI/link. MP-MRI multiparametric magnetic resonance imaging, PFB-CEUS perfluorobutane contrast-enhanced ultrasound, DWI diffusion weighted imaging, ADC apparent diffusion coefficient, DCE-MRI dynamic contrast-enhanced magnetic resonance imaging, BPE background parenchymal enhancement, TIC time–intensity curve, FT fall time, MP malignant probability