Fig. 3

Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for selected site-specific second primary cancers among 16,004 women diagnosed with a first primary unilateral invasive breast cancer between 1990 to 2016 and followed through 2017. Abbreviations: SIRs–Standardized incidence ratios, CIs–Confidence intervals, O–Observed, E–Expected. ^aCancer sites with ≥ 10 cases are presented unless specified a priori as a site of interest. ^bWomen with bilateral mastectomies were excluded (n = 1,042). ^cLeukemia subtypes not presented include acute lymphocytic leukemia (n = 2), chronic myeloid leukemia (n = 6), other leukemia (n = 2). ^dAnalyses for myelodysplastic syndrome are restricted to 2001–2017 since SEER did not systematically ascertain this outcome prior to this date