Fig. 4
From: Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β
The CLDN4 signaling regulates the expression of genes relating to cholesterol homeostasis and fatty acid metabolism in breast cancer cells. A Gene set enrichment analysis (GSEA) of ranked differential gene scores showing the CLDN4-dependent enrichment of gene sets of adipogenesis, bile acid metabolism, cholesterol homeostasis, and fatty acid metabolism in T47D and MCF-7 cells. B Waterfall plot showing the alteration of the gene expression by CLDN4-KO in T47D and MCF-7 cells. Genes showing significant changes in gene ontology (GO) cholesterol homeostasis (GO:0042632) and fatty acid homeostasis (GO:0055089) are indicated in red and blue dots, respectively. C, D The intracellular levels of cholesterol (C) and triglyceride (D) in T47D and T47D:CLDN4–/– cells are plotted and shown in histograms (mean ± SD; n = 5)