Fig. 1
From: TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects
Comparison of mutational profiles for tumours with and without TP53 somatic mutations. a Total number of somatic alterations [single nucleotide variants (SNVs)] and indels identified in mutant and wild-type TP53 tumours, within each individual PAM50 subtype as well as overall (“TP53”), with germline and somatic BRCA mutated tumours (“BRCA”) included for comparison. b The stacked bar plot demonstrates the proportion of major mutational signatures in between mutant TP53 and wild-type TP53 across subtypes. c Comparison of genomic scar scores for mutant TP53 tumours and wild-type TP53 tumours. Boxplots represent medians (centre line) and interquartile range, and whiskers represent the maximum and minimum values within 1.5 times the interquartile range from the edge of the box. Each data point represents an individual sample. P values are derived from Mann–Whitney U tests for figures a and c and Chi-square tests for figure b