Fig. 7

Both β-catenin and WAVE3 expression levels correlate with the aggressiveness of breast cancer and with poor outcome in BC patients. A Representative Western blots of protein lysates from the indicated breast cancer cell lines that were subjected to immunoblotting with antibodies against WAVE3 (upper panel) or β-catenin (middle panel). β-Actin (lower panel) was used as loading control. Data shown are representative of 3 replicates. B, C Breast Cancer Kaplan–Meier plotter (KM, http://kmplot.com/analysis/) correlating survival of triple negative breast cancer patients with expression levels of WASF3/WAVE3 (B) and CTNNB1/β-catenin (C). High WAVE3 and β-catenin expression levels correlate with poor survival probability in BC patients. D Interrogation of the TCGA breast cancer PanCancer Atlas cohort (n = 803 BC patients) showed a significant (p < 2.2e-16) positive correlation between WAVE3 and β-catenin mRNA expression levels