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Table 2 Multivariable-adjusted regressions between adiposity measures, weight changes and mammographic density at first digital mammographic examination among 5262 women in the FEDRA study (VPD = Volumetric percent density; DV = dense volume; BMI = body mass index; 95% CI = 95% confidence interval) a

From: Lifetime changes in body fatness and breast density in postmenopausal women: the FEDRA study

 

VPD (%)

DV (cm3)

NDV (cm3)

 

%Diff (95% CI)b

p-value

%Diff (95% CI)b

p-value

%Diff (95% CI)b

p-value

BMI at age 20 years (kg/m2)

− 4.42

(− 5.05 to − 3.78)

 < 0.0001

0.93

(0.37 to 1.50)

0.001

5.98

(5.24 to 6.71)

 < 0.0001

BMI at age 40 years (kg/m2)

− 6.59

(− 7.07 to − 6.11)

 < 0.0001

2.20

(1.74 to 2.67)

 < 0.0001

10.07

(9.52 to 10.63)

 < 0.0001

BMI at EPIC enrollment (kg/m2)

− 6.23

(− 6.57 to − 5.89)

 < 0.0001

1.95

(1.61 to 2.29)

 < 0.0001

9.34

(8.95 to 9.73)

 < 0.0001

BMI at follow-up (kg/m2)

− 6.32

(− 6.62 to − 6.02)

 < 0.0001

1.98

(1.68 to 2.29)

 < 0.0001

9.51

(9.18 to 9.84)

 < 0.0001

Annual weight change from age 20 to age 40 (kg/year)c

− 44.91

(− 47.76 to − 41.90)

 < 0.0001

23.61

(17.88 to 29.62)

 < 0.0001

136.79

(124.79 to 149.44)

 < 0.0001

Annual weight change from age 40 to EPIC enrollment (kg/year)c

− 5.82

(− 7.17 to − 4.45)

 < 0.0001

1.97

(0.72 to 3.24)

0.002

8.85

(7.26 to 10.46)

 < 0.0001

Annual weight change from EPIC enrollment to follow-up (kg/year)c

-17.64

(− 19.99 to − 15.21)

 < 0.0001

5.99

(3.37 to 8.68)

 < 0.0001

31.24

(27.39 to 35.20)

 < 0.0001

Weight change from age 20 to age 40 (kg)c

      

Weight gain > 10 kg

− 37.71

(− 40.93 to − 34.32)

 < 0.0001

19.74

(14.20 to 25.54)

 < 0.0001

100.83

(90.81 to 111.38)

 < 0.0001

Weight gain > 5—≤ 10 kg

− 31.87

(− 35.00 to − 28.58)

 < 0.0001

14.00

(9.30 to 18.90)

 < 0.0001

73.75

(66.01 to 81.85)

 < 0.0001

Weight gain > 2—≤ 5 kg

− 19.64

(− 23.22 to − 15.89)

 < 0.0001

5.42

(1.21 to 9.81)

0.01

34.38

(28.58 to 40.44)

 < 0.0001

Stable weight (± 2 kg)

1.00 (ref.)

 

1.00 (ref.)

 

1.00 (ref.)

 

Weight loss > 2 kg

19.97

(11.40 to 29.20)

 < 0.0001

-7.13

(-13.08 to -0.76)

0.03

-24.04

(-29.30 to -18.40)

 < 0.0001

Weight change from age 40 to EPIC enrollment (kg)c

      

Weight gain > 10 kg

− 35.91

(− 39.48 to − 32.12)

 < 0.0001

13.97

(8.37 to 19.86)

 < 0.0001

84.68

(74.45 to 95.51)

 < 0.0001

Weight gain > 5—≤ 10 kg

− 25.80

(− 29.34 to − 22.08)

 < 0.0001

6.12

(1.66 to 10.78)

0.007

46.95

(40.00 to 54.27)

 < 0.0001

Weight gain > 2—≤ 5 kg

− 13.59

(− 17.64 to 9.34)

 < 0.0001

5.70

(1.33 to 10.26)

0.01

23.80

(18.04 to 29.85)

 < 0.0001

Stable weight (± 2 kg)

1.00 (ref.)

 

1.00 (ref.)

 

1.00 (ref.)

 

Weight loss > 2 kg

− 4.74

(− 11.77 to 2.84)

0.21

2.14

(− 4.52 to 9.25)

0.54

7.36

(− 0.51 to 15.86)

0.07

Weight change from EPIC enrollment to follow-up (kg)c

      

Weight gain > 10 kg

− 33.96

(− 38.47 to − 29.11)

 < 0.0001

11.73

(5.09 to 18.79)

0.0004

75.61

(63.40 to 88.74)

 < 0.0001

Weight gain > 5—≤ 10 kg

− 21.56

(− 25.19 to − 17.76)

 < 0.0001

10.25

(5.82 to 14.86)

 < 0.0001

43.99

(37.21 to 51.10)

 < 0.0001

Weight gain > 2—≤ 5 kg

− 8.45

(− 12.26 to 4.47)

 < 0.0001

5.00

(1.21 to 8.93)

0.01

15.73

(10.83 to 20.84)

 < 0.0001

Stable weight (± 2 kg)

1.00 (ref.)

 

1.00 (ref.)

 

1.00 (ref.)

 

Weight loss > 2 kg

1.86

(− 2.76 to 6.70)

0.44

− 0.58

(− 4.50 to 3.49)

0.78

-2.82

(− 7.30 to 1.)

0.24

  1. a All models were adjusted for age at mammographic examination, birth index, postmenopausal status (enrollment, yes/no), age at menarche
  2. b The %Diff represents the percent change of VPD or DV or NDV associated to one unit change in BMI or 1 kg/year of weight gain or with respect to the stable weight group
  3. c Model additionally adjusted for BMI at age 20
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Breast Cancer Research

ISSN: 1465-542X

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