Fig. 7

miR-214-5P mimic downregulates RAD51 and synergizes with olaparib. A Comet assay representative images of MDAMB468 cells transfected with miR-control or miR-214-5P and treated with or without 25 µM olaparib for 24 h. B MDAMB468 and C HCC1806 analysis of comet tail area in more than 25 cells from three different experiments with their standard deviation as the error bars. D High-density colony assay plates of HCC1806 cells transfected with miR-control or miR-214-5P and treated with different concentrations of olaparib. E Low-density colony assay plates of MDAMB468 cells transfected with miR-control or miR-214-5P and treated with varying concentrations of olaparib. F Survival fraction of MDAMB468 cells transfected with miR-control or miR-214-5P and treated with varying concentrations of olaparib in three independent experiments. G Survival fraction of HCC1806 cells transfected with miR-control or miR-214-5P and treated with varying concentrations of olaparib in three independent experiments