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Fig. 5 | Breast Cancer Research

Fig. 5

From: Transcriptomic alterations underlying metaplasia into specific metaplastic components in metaplastic breast carcinoma

Fig. 5

Differentially expressed BC360-defined signatures of the NST components and paired metaplastic components. A Heat map of differences in the expression of BC360-defined signatures in the NST and paired metaplastic components, with signatures exhibiting significant differences (paired t test, p < 0.05) labeled with asterisks. Log2 fold-change indicates log2 fold-change of the gene signature score of the metaplastic component with respect to the NST component. Plotted figures demonstrate the differences in the expression of representative genes and the GSEA-based activity of gene sets in the B SPS, C RHA, D SQC, and E MAT with respect to their paired NST components. A paired t test was conducted to evaluate differences in expression. Gene sets were obtained from MSigDB. E Heat map (right panel) of the expression of leading-edge genes from the GSEA results for the NST and MAT components (left panel)

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Breast Cancer Research

ISSN: 1465-542X

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