Fig. 3

Transcriptomic differences among the NST components and metaplastic components. A Heat map of 758 genes (excluding housekeeping genes and probes for internal control) across 59 specimens obtained from 27 patients with MpBC. PID, patient identification. B PCA plot of unsupervised clustering among the 59 specimens. C Distribution of between-sample differences quantified based on the Euclidean distances of expression profiles in the NST components and distinct metaplastic components. D PCA plot identical to B but with NST components and paired metaplastic component linked by arrows, illustrating subtype-specific differentiation. E Euclidean distance based on expression profiles among NST components and metaplastic components in four patients with MpBC involving multiple metaplastic components