Fig. 1

Stratified analyses of breast cancer associations. Associations of the metabolites associated with breast cancer at FDR < 0.20 grouped in correlated blocks (A) in pre- and postmenopausal women, and (B) in women with ER+ or ER− breast cancer. Associations marked with † differed significantly (p < 0.05) between the two groups. An * next to a metabolite name indicates a level two (putative annotation) compound identification, whereas level one (definitive) identification requires comparing two or more properties of the metabolite, such as retention time, m/z, or fragmentation mass spectrum, to those for an authentic chemical standard, level two (putative) identification requires comparison of only one of these properties