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Table 2 Association of childhood BMI Z-score with young adult breast density phenotypes

From: Childhood adiposity, serum metabolites and breast density in young women

Phenotype

Minimally adjusted modela

Fully adjusted modelb

Δ/unit BMI

95% CI

P-value

Δ/unit BMI

95% CI

P-value

Breast density (%)

− 3.60

− 6.30, − 0.90

9.70E−03

− 3.43

− 6.04, − 0.82

1.09E−02

Dense breast Volume (cm3)

− 24.36%

− 34.66%, − 12.43%

2.52E−04

− 24.44%

− 34.27%, − 13.14%

1.18E−04

Non-dense breast volume (cm3)

− 8.59%

− 17.02%, 0.69%

7.05E−02

− 8.57%

− 17.04%, 0.78%

7.30E−02

  1. aEstimates are from robust mixed effects multivariable linear regression models including breast density phenotype as the dependent variable; childhood BMI z-score (continuous), age at childhood BMI measurement (continuous), treatment group assignment, BMI and BMI2 at breast density measurement in young adulthood (continuous) as fixed effects; and DISC clinic as a random effect
  2. bEstimates are from robust mixed effects multivariable linear regression models as described above under (1) plus fixed effects for race (white/nonwhite), college graduate (yes/no), duration hormone use (continuous), number live births (0/1+) and current smoker (yes/no)
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Breast Cancer Research

ISSN: 1465-542X

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