Fig. 4

Z scores from GWAS of V, MD phenotypes, and breast cancer risk for SNPs included in SNP-set test. a scatter plots of Z scores from GWAS of V by Z scores from GWAS of percent density (PD), dense area (DA), and non-dense area (NDA) for mammographic density SNPs; b scatter plots of Z scores from GWAS of V by Z scores from GWAS of overall breast cancer risk and stratified by estrogen receptor (ER) status for breast cancer SNPs. For each SNP, GWAS results from Models 0 and 2 for VSUM are shown with gray and red dots, respectively. RS number for some SNPs are not shown on the plots. Gray line is the fitted linear regression line of Z scores for results from Model 0; red line is the fitted linear regression line of Z scores for results from Model 2. Note that some of the overall breast cancer risk SNPs are not genome-wide significant because we obtained the Z scores from one study and those SNPs were reported by other studies. GWAS genome-wide association study, MD mammographic density, SNP single-nucleotide polymorphism