Fig. 8

SRC-3 KD suppresses the 4T1 breast cancer progression in BALB/cJ female mice. A Western blot analysis of the SRC-3 levels in paternal 4T1 cells and 4T1 cells expressing a nontargeting (NT) shRNA and shRNA against mouse SRC-3. B Luciferase activity imaging analysis of the growth of luciferase-labeled SRC-3 KD 4T1 breast tumors and control luciferase-labeled 4T1 breast tumors expressing the nontargeting shRNA in BALB/cJ female mice. C Quantification of the luciferase activity of luciferase-labeled SRC-3 KD 4T1 and KD control 4T1 breast tumors in Panel B. D SRC-3 KD and control breast tumors harvested from tumor-bearing BALB/cJ mice on the 21st day after the injection of cancer cells. E Quantification of the volume of SRC-3 KD and control breast tumors in Panel D. Tumor volume was calculated as 0.5 x length × width × width