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Fig. 3 | Breast Cancer Research

Fig. 3

From: Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction

Fig. 3

Oncomine Nox4 analysis in breast cancer. The heatmap represents the relative expression in patients with the indicated breast carcinomas compared with normal tissue. Red box indicates overexpression, while white box indicates insignificant change. The reported median rank and P value consider all indicated studies simultaneously. (A) Comparison of Nox4 expression across 9 breast cancer epithelial analyses. (B) Comparison of Nox4 expression in 5 subsets of breast cancer stroma analyses. (C) Box plots derived from Nox4-gene expression data comparing stroma of invasive breast carcinomas to normal breast stroma from 3 breast stroma studies. The number of samples in each group is indicated in brackets. (D) Heat map and median rank comparison of significant differential expression (breast cancer stroma versus normal breast stroma) of all 7 Nox isoforms in the following studies: 1—Ma4 Breast, 2—Finak Breast, and 3—Karnoub Breast

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Breast Cancer Research

ISSN: 1465-542X

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