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Fig. 6 | Breast Cancer Research

Fig. 6

From: Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

Fig. 6

Tumorigenic capacity of Dusp4NULL Trp53Δ MYCAMP cells is associated with chromosome 5 amplification. A Whole-genome sequencing of PMEC-derived cell lines with Dusp4 loss, Trp53 loss, and/or MYC amplification. Dusp4NULL Trp53Δex7 MYCAMP cells (tumor forming) or Dusp4FLOX Trp53Δex7 MYCAMP cells (not tumor forming). B FISH for chromosome 5 centromeric amplicon in DPM tumors compared to normal murine mammary gland tissue. C Representative images of FISH in metaphase spreads from DPM and Dusp4FLOX cells. In the right panel is a magnification of chromosome 5

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Breast Cancer Research

ISSN: 1465-542X

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