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Fig. 2 | Breast Cancer Research

Fig. 2

From: Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer

Fig. 2

Weight Maintenance after OVX improves markers of metabolic function in lean and obese rats. AC Blood was collected from fasted rats at the end of study and glucose (A) and insulin (B) were measured and used to calculate HOMA-IR (C). Filled circles indicate rats assigned to AdLib, open squares indicate rats assigned to WM. Two-way ANOVA, main effects of adiposity or WM. D Quantification of adipophilin in liver sections from lean and obese AdLib or WM rats at the end of study, measured by IHC. Two-way ANOVA, main effects of adiposity or WM. E Representative images of liver adipophilin staining. Scale bar is 250 µm. F Mass of visceral [mesenteric (Mes; light gray), retroperitoneal (RP; red), and gonadal (Gon; dark gray)] adipose depots in lean and obese AdLib or WM rats at the end of study

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