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Fig. 7 | Breast Cancer Research

Fig. 7

From: Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling

Fig. 7

A schematic diagram showing a proposed mechanism by which beta-adrenergic receptor (B2AR) and mu-opioid receptor (MOR) interact and regulate tumor aggressiveness in human breast cancer cells. B2AR and MOR interaction via receptor dimerization increases GSK3 signaling in triple-negative MDA-MB-231 and MDA-MB-468 breast cancer cells. Increased GSK3 signaling via activation of NOTCH, MUC1, and STAT3 increases cell proliferation, colony formation, cell migration, and metastasis

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Breast Cancer Research

ISSN: 1465-542X

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