Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women

Table 2 Correlations between hormones and RANK pathway gene expression in postmenopausal women

Gene	Mean (Range)	Age	BMI	PRL	ESR1	PGR	STAT1	STAT5	RANK	RANKL	OPG	TNFRSF13B	TNFRSF18
PRL	5.81 (4.60–6.83)	0.05	− 0.05	1.00	0.01	0.25	0.25	0.39	− 0.16	0.02	0.28	− 0.18	0.24
		p = 0.34	p = 0.28		p = 0.79	p < 0.01	p < 0.01	p < 0.01	p < 0.01	p = 0.70	p < 0.01	p < 0.01	p < 0.01
ESR1	5.38 (4.42–7.42)	0.01	0.07		1.00	0.43	− 0.11	− 0.09	0.27	0.08	0.41	0.20	0.22
		p = 0.99	p = 0.17			p < 0.01	p = 0.04	p = 0.08	p < 0.01	p = 0.10	p < 0.01	p < 0.01	p < 0.01
PGR	4.4 (3.08–7.00)	0.08	− 0.04			1.00	− 0.15	− 0.05	0.25	0.10	0.65	0.10	0.30
		p = 0.20	p = 0.42				p < 0.01	p = 0.36	p < 0.01	p = 0.05	p < 0.01	p = 0.04	p < 0.01
STAT1	14.62 (10.79–16.86)	0.04	− 0.07				1.00	0.59	− 0.17	− 0.02	− 0.15	− 0.22	0.20
		p = 0.43	p = 0.18					p < 0.01	p < 0.01	p = 0.65	p < 0.01	p < 0.01	p < 0.01
STAT5	11.93 (8.09–12.99)	0.03	0.06					1.00	− 0.21	− 0.06	− 0.08	− 0.06	0.35
		p = 0.50	p = 0.22						p < 0.01	p = 0.24	p = 0.11	p = 0.25	p < 0.01
RANK	6.33 (5.72–6.93)	− 0.02	− 0.18						1.00	0.15	0.17	0.19	0.32
		p = 0.64	p < 0.01							p < 0.01	p < 0.01	p < 0.01	p < 0.01
RANKL	2.93 (2.16–3.70)	0.07	− 0.16							1.00	0.17	− 0.01	0.14
		p = 0.19	p < 0.01								p < 0.01	p = 0.90	p < 0.01
OPG	4.12 (3.57–4.67)	0.04	− 0.10								1.00	0.07	0.25
		p = 0.40	p = 0.04									p = 0.14	p < 0.01
TNFRSF13B	6.70 (6.09–7.31)	− 0.12	− 0.12									1.00	0.23
		p = 0.02	p = 0.02										p < 0.01
TNFRSF18	7.42 (7.04–7.80)	0.01	− 0.13										1.00
		p = 0.92	p = 0.01

Pearson’s correlation coefficients were calculated. Gene expression levels were log2 transformed
BMI Body Mass Index (kg/m²)
^*Statistically significant correlations (p < 0.05) are in bold

ISSN: 1465-542X