Fig. 7
From: SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistance
PELP1 is needed for SETDB1 mediated BC progression. A MCF7-Control, MCF7-SETDB1, MCF7-PELP1-KD, MCF7-PELP1-KD + SETDB1 cells were implanted into SCID mice (n = 5) and tumor growth was measured at indicated time points. B–E Tumor sections were immunostained for status of Ki-67 (B) and p-Akt(S473) (C) expression and quantitation (D, E). Representative IHC images of Ki67 and p-Akt(S473) are shown. F Pearson’s pairwise correlation between SETDB1 and PELP1 in ER+ BC patients was plotted with bc-GenExMiner using a TCGA dataset. G Schematic model depicting PELP1-SETDB1 axis in mediating AKT signaling in ER+ BC. Data was represented as mean ± SEM. ****p < 0.0001