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Fig. 4 | Breast Cancer Research

Fig. 4

From: KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway

Fig. 4

KRT13 induces stem cell properties and malignant progression through c-Myc activation. The expression of c-Myc was molecularly manipulated in KRT13-overexpressing or KRT13-knockdown breast cancer cells. A c-Myc silencing in MCF7-KRT13 cells and c-Myc overexpression in HCC1954-shKRT13 cells. Western blot revealed that changes in c-Myc level caused similar changes in CD44 and Nanog proteins. B c-Myc silencing inhibited mammosphere formation, while c-Myc overexpression reversed the effect of shKRT13. C c-Myc silencing reduced MCF7-KRT13 cell growth. D c-Myc silencing inhibited MCF7-KRT13 cell migration and invasion. E c-Myc overexpression increased HCC1954-shKRT13 cell growth. F c-Myc overexpression increased HCC1954-shKRT13 cell migration and invasion. For all presentations, *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001)

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Breast Cancer Research

ISSN: 1465-542X

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