Fig. 7

A schematic summary of triptonide-mediated inhibition of triple-negative breast cancer cell tumorigenesis and metastasis. Triptonide enters to TNBC cells and triggers the degradation of oncogenic Twist1 and Notch1 proteins, consequently inhibiting their downstream NF-κB signaling, and reducing the expression of angiogenic VE-cadherin and VEGFR2, and EMT-inducing N-cadherin. As a result, triptonide potently suppressed TNBC cell tumorigenesis, migration, invasion, and angiogenesis, tumor growth, and lung metastasis in xenografted mice