Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy

Table 3 Associations of collagen fiber characteristics with the overall biopsy diagnosis among women undergoing diagnostic breast biopsy

	Fiber characteristics measured in all ROIs		Fiber characteristics measured in benign and cancer ROIs only
	OR (95% CI)	p Value	OR (95% CI)	p Value
Average length (μm)	1.17 (0.80, 1.70)	0.416	1.01 (0.61, 1.68)	0.963
Median straightness	0.97 (0.65, 1.44)	0.881	0.96 (0.61, 1.51)	0.845
Average width (μm)	1.08 (0.76, 1.53)	0.678	1.03 (0.70, 1.52)	0.878
Median alignment (in 44.91 μm × 44.91 μm)	0.93 (0.66, 1.31)	0.675	0.91 (0.60, 1.40)	0.68
Density (number of fibers/100 μm²)	1.24 (0.86, 1.78)	0.248	1.12 (0.73, 1.72)	0.618
Median orientation (°)	1.43 (0.83, 2.47)	0.192	1.78 (0.93, 3.40)	0.08

Based on generalized estimating equation (GEE) models with independent correlation structure. Outcomes of the models were the overall diagnosis of the woman. Collagen fiber characteristics were the independent variables of the models. Models also included the diagnosis of the ROIs. OR is per 1-standard deviation of the fiber characteristic

ISSN: 1465-542X