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Table 4 Association between HIF-1α expression and breast cancer recurrence by quintile of recurrence time and ER/TAM group among 1682 subjects from the ProBe CaRe population-based case control study

From: Hypoxia-inducible factor-1α expression and breast cancer recurrence in a Danish population-based case control study

Time to recurrence

Median time to recurrence (yaers)

ER+/TAM+ breast cancer patients

ER−/TAM− breast cancer patients

Cases/controls

Adjusted OR (95% CI)a

Cases/controls

Adjusted OR 95% CI)a

1 to < 2

1.5

109/113

1.03 (0.54, 1.96)

113/105

0.73 (0.42, 1.27)

2 to < 3

2.4

80/85

1.16 (0.55, 2.44)

67/72

0.74 (0.36, 1.54)

3 to < 4

3.4

88/78

3.41 (1.28, 9.06)

32/33

2.50 (0.81, 7.68)

4 to < 6

4.7

113/115

0.79 (0.41, 1.52)

27/27

0.76 (0.22, 2.60)

6–10

7.3

68/73

1.39 (0.59, 3.30)

19/17

5.78 (0.61, 55.0)

  1. CI, confidence interval; ER, estrogen receptor; OR, odds ratio; TAM, tamoxifen; y, years
  2. aAdjusted for matching factors (menopausal status, surgery date, county of residence, stage, age category) and chemotherapy, radiation therapy, and tamoxifen duration (ER+ stratum only)