Table 1 Distribution of tumor and patient characteristics among breast cancer recurrence cases and controls by ER/TAM group among 1682 subjects from the ProBe CaRe population-based case control study
Patient characteristic | ER+/TAM+, N (%) | ER−/TAM−, N (%) | ||||
|---|---|---|---|---|---|---|
Case | Control | Case | Control | |||
HIF-1α expression | ||||||
Positive | 106 (23) | 93 (20) | 122 (47) | 122 (48) | ||
Negative | 352 (77) | 371 (80) | 136 (53) | 132 (52) | ||
Missing | 83 | 77 | 42 | 46 | ||
Diagnosis year | ||||||
1985–1993 | 235 (43) | 234 (43) | 107 (36) | 100 (33) | ||
1994–1996 | 113 (21) | 112 (30) | 81 (27) | 83 (28) | ||
1997–2001 | 193 (36) | 195 (36) | 112 (37) | 117 (39) | ||
Age category at diagnosis | ||||||
35–44 | 16 (3.1) | 13 (2.4) | 68 (23) | 58 (19) | ||
45–54 | 116 (21) | 111 (21) | 120 (40) | 113 (38) | ||
55–64 | 286 (53) | 281 (52) | 82 (27) | 86 (29) | ||
65–69 | 123 (23) | 136 (25) | 30 (10) | 43 (14) | ||
Menopausal status at diagnosis | ||||||
Premenopausal | 34 (6.3) | 34 (6.3) | 121 (40) | 121 (40) | ||
Postmenopausal | 507 (94) | 507 (94) | 179 (60) | 176 (60) | ||
UICC tumor stage at diagnosis | ||||||
I | 9 (1.7) | 9 (1.7) | 25 (8.3) | 25 (8.3) | ||
II | 250 (46) | 250 (46) | 153 (51) | 153 (51) | ||
III | 282 (52) | 282 (52) | 122 (41) | 122 (41) | ||
Histological grade | ||||||
I | 108 (25) | 144 (35) | 27 (11) | 23 (10) | ||
II | 234 (54) | 215 (52) | 125 (49) | 98 (43) | ||
III | 92 (21) | 57 (14) | 103 (40) | 106 (47) | ||
Missing | 107 | 125 | 45 | 73 | ||
Surgery type | ||||||
Breast-conserving surgery | 58 (11) | 71 (13) | 47 (16) | 56 (19) | ||
Mastectomy | 483 (89) | 470 (87) | 252 (84) | 244 (81) | ||
Radiation therapy | ||||||
Yes | 183 (34) | 191 (35) | 128 (44) | 123 (47) | ||
No | 358 (66) | 350 (65) | 166 (56) | 137 (53) | ||
Missing | 6 | 40 | ||||
Systemic adjuvant chemotherapy | ||||||
Yes | 70 (13) | 65 (12) | 248 (83) | 188 (63) | ||
No | 471 (87) | 476 (88) | 52 (17) | 112 (37) | ||
Tamoxifen protocol, years | ||||||
1 | 257 (48) | 261 (48) | ||||
2 | 98 (18) | 92 (18) | ||||
5 | 186 (34) | 188 (34) | ||||