Fig. 1
From: Secreted indicators of androgen receptor activity in breast cancer pre-clinical models
KLK3, AZGP1 and PIP are the most DHT-responsive genes that also encode secreted proteins. a Gene expression profile of HCI-009 PDX tumor in mice supplemented with cellulose, as a control, or DHT, assessed by RNA-seq. Gene set X consist of163 genes significantly up-regulated (fold change ≥ 1.5, q < 0.05) in HCI-009 PDX tumors from mice treated with DHT compared with controls and is defined as the androgen responsive gene set. Gene set Y consist of genes encoding proteins listed in secretome of breast cancer cell lines reported by Ziegler YS, et al. (2016). b Fold change expression of genes in DHT treated mice relative to control mice in descending order. Each dot represents a gene, and white circles represent genes encoding secreted proteins and are accompanied by official gene symbols