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Table 4 Hazard ratios for incident CAD events in interaction models adjusted for baseline mediators

From: Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study

Interaction Model Hazard Ratio (95% CI) P value
With BMI*   
PRS 1.31 (1.18, 1.46) 1.5 × 10–7
log(BMI) 1.24 (1.12, 1.37) 2.0 × 10–5
PRS*log(BMI) 1.07 (0.97, 1.18) 0.17
With smoking   
PRS 1.24 (1.06, 1.44) 4.0 × 10–3
Past smoker 1.26 (1.00, 1.58) 0.044
Current smoker 1.72 (1.31, 2.27) 9.1 × 10–5
PRS*past smoker 1.23 (0.98, 1.53) 0.069
PRS*current smoker 1.03 (0.79, 1.34) 0.82
  1. Baseline mediators include age, genotype array, 8 genetic PCs, log(BMI), smoking, education level, drinking, parity, hormone replacement therapy
  2. *log(BMI) was scaled to its mean