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Table 2 Age-adjusted univariate associations of baseline characteristics and incident CAD

From: Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study

Variable Hazard Ratio (95% CI) P value
PRS 1.36 (1.23, 1.50) 6.0 × 10–10
Sociodemographic   
Log(IMD) 1.25 (1.08, 1.45) 1.9 × 10–3
Education Level*   
GSCE or similar 0.65 (0.51, 0.82) 2.0 × 10–4
A-level or similar 0.60 (0.42, 0.85) 3.8 × 10–3
Graduate 0.50 (0.34, 0.74) 4.6 × 10–4
Lifestyle   
Log(BMI) 5.11 (3.05, 8.6) 6.1 × 10–10
Smoking   
Past 1.44 (1.16, 1.78) 8.2 × 10–4
Current 1.93 (1.50, 2.51) 4.8 × 10–7
Drinking†† 0.63 (0.51, 0.76) 1.6 × 10–6
Medical   
Age at menarche 0.98 (0.92, 1.05) 0.56
Parity (number of full-term pregnancies) 1.12 (1.05, 1.21) 7.6 × 10–4
Hormone replacement therapy 1.17 (0.96, 1.42) 0.11
Thyroid disease 1.16 (0.87, 1.54) 0.29
Oncotherapy   
Chemotherapy 1.02 (0.81, 1.28) 0.87
Radiotherapy 0.93 (0.75, 1.16) 0.53
Hormone therapy 0.84 (0.66, 1.07) 0.15
  1. All univariable models were fit to the same sample. All models adjusted for age, genotype array, and 8 genetic PCs
  2. *Education reference category is below GSCE
  3. Smoking reference category is never-smokers
  4. ††Drinking reference category is past-drinkers