Variable | Hazard Ratio (95% CI) | P value |
---|---|---|
PRS | 1.36 (1.23, 1.50) | 6.0 × 10–10 |
Sociodemographic | ||
Log(IMD) | 1.25 (1.08, 1.45) | 1.9 × 10–3 |
Education Level* | ||
GSCE or similar | 0.65 (0.51, 0.82) | 2.0 × 10–4 |
A-level or similar | 0.60 (0.42, 0.85) | 3.8 × 10–3 |
Graduate | 0.50 (0.34, 0.74) | 4.6 × 10–4 |
Lifestyle | ||
Log(BMI) | 5.11 (3.05, 8.6) | 6.1 × 10–10 |
Smoking† | ||
Past | 1.44 (1.16, 1.78) | 8.2 × 10–4 |
Current | 1.93 (1.50, 2.51) | 4.8 × 10–7 |
Drinking†† | 0.63 (0.51, 0.76) | 1.6 × 10–6 |
Medical | ||
Age at menarche | 0.98 (0.92, 1.05) | 0.56 |
Parity (number of full-term pregnancies) | 1.12 (1.05, 1.21) | 7.6 × 10–4 |
Hormone replacement therapy | 1.17 (0.96, 1.42) | 0.11 |
Thyroid disease | 1.16 (0.87, 1.54) | 0.29 |
Oncotherapy | ||
Chemotherapy | 1.02 (0.81, 1.28) | 0.87 |
Radiotherapy | 0.93 (0.75, 1.16) | 0.53 |
Hormone therapy | 0.84 (0.66, 1.07) | 0.15 |