Characteristic | Cases with p-mTOR overexpressed tumors (n = 192)a | Cases with p-mTOR negative/low tumors (n = 523) | Controls (n = 1983) | P value (p-mTOR overexpressed vs controls)b | P value (p-mTOR negative/low vs controls)b | P value (p-mTOR overexpressed vs p-mTOR negative/low)b |
---|---|---|---|---|---|---|
Age, mean (SD), years | 53.8 (10.7) | 52.5 (11.1) | 48.6 (9.4) | < 0.001 | < 0.001 | 0.16 |
Race, no. (%) | Â | Â | Â | Â | Â | Â |
 Black | 159 (82.8) | 415 (79.4 ) | 1270 (64.0) | < 0.001 | < 0.001 | 0.30 |
 White | 33 (17.2) | 108 (20.6) | 713 (36.0) |  |  |  |
Menopausal status, no. (%) | Â | Â | Â | Â | Â | Â |
 Premenopausal | 86 (44.8) | 241 (46.1) | 982 (49.5) | 0.21 | 0.16 | 0.76 |
 Postmenopausal | 106 (55.2) | 282 (53.9) | 1001 (50.5) |  |  |  |
BMI, kg/m2, no. (%) | Â | Â | Â | Â | Â | Â |
  < 25.0 | 31 (16.2) | 121 (23.1) | 553 (27.9) | 0.001 | 0.010 | 0.033 |
 25.0–29.9 | 49 (25.5) | 150 (28.7) | 534 (26.9) |  |  |  |
 30.0–34.9 | 51 (26.6) | 135 (25.8) | 400 (20.2) |  |  |  |
  ≥ 35.0 | 61 (31.8) | 117 (22.4) | 496 (25.0) |  |  |  |
WC, inches, no. | 190 | 513 | 1965 | Â | Â | Â |
 Mean (SD) | 102.8 (17.9) | 98.2 (14.7) | 96.7 (17.1) | < 0.001 | 0.07 | 0.002 |
WHR, no. | 190 | 513 | 1965 | Â | Â | Â |
 Mean (SD) | 0.88 (0.08) | 0.88 (0.09) | 0.86 (0.09) | < 0.001 | < 0.001 | 0.29 |
Percentage body fat, no. | 182 | 496 | 1893 | Â | Â | Â |
 Mean (SD), % | 41.1 (7.6) | 39.2 (7.6) | 38.8 (8.8) | < 0.001 | 0.22 | 0.006 |
Fat mass index, no. | 181 | 495 | 1868 | Â | Â | Â |
 Mean (SD), kg/m2 | 13.8 (5.1) | 12.3 (4.7) | 12.3 (5.7) | < 0.001 | 0.78 | < 0.001 |
ER status, no. (%) | Â | Â | Â | Â | Â | Â |
 Positive | 167 (87.0) | 310 (59.5) | – | – | – | < 0.001 |
 Negative | 25 (13.0) | 211 (40.5) | – | – | – |  |
PR status, no. (%) | Â | Â | Â | Â | Â | Â |
 Positive | 163 (85.8) | 308 (59.2) | – | – | – | < 0.001 |
 Negative | 27 (14.2) | 213 (40.9) | – | – | – |  |
HER2 status, no. (%) | Â | Â | Â | Â | Â | Â |
 Positive | 31 (17.2) | 111 (22.0) | – | – | – | 0.18 |
 Negative | 149 (82.8) | 394 (78.0) | – | – | – |  |