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Table 2 Adjusted means of PMD across quartiles of PCaeC30:2 and SMC16:1, overall and by BMI

From: Biomarkers of mammographic density in premenopausal women

  

Quartiles of metabolites plasma concentrations

 
  

Q1

Q2

Q3

Q4

 

Metabolite

 

Adjusted mean PMD1 (95 % CI)

Adjusted mean PMD1 (95% CI)

Adjusted mean PMD1 (95% CI)

Adjusted mean PMD1 (95% CI)

P trend2

SM C16:1

Overall

38.1 (32.2–44.0)

39.8 (34.1–45.5)

36.6 (30.9–42.2)

32.0 (26.3–37.8)

< 0.01

 

BMI (kg/m2)

     

n = 286

< 27.4

43.7 (35.7–51.8)

41.7 (33.7–49.7)

39.6 (31.8–47.3)

35.1 (27.1–43.1)

< 0.01

n = 287

≥ 27.4

29.6 (19.1–40.1)

35.4 (25.3–45.6)

29.7 (19.8–39.5)

25.9 (15.7–36.1)

0.07

     

P interaction3

0.51

PC ae C30:2

Overall

40.7 (34.9–46.5)

37.6 (31.8–43.5)

34.5 (28.8–40.1)

35.0 (29.2–40.8)

< 0.01

 

BMI (kg/m2)

     

n = 286

< 27.4

42.4 (34.4–50.4)

42.2 (34.1–50.2)

36.8 (29.0–44.6)

38.5 (30.4–46.7)

0.09

n = 287

≥ 27.4

36.8 (26.2–47.3)

31.6 (21.4–41.9)

29.8 (20.0–39.6)

28.6 (18.3–38.8)

< 0.01

     

P interaction3

0.31

  1. Abbreviations: ae acyl-alkyl; BMI body mass index; CI confidence interval; PC phosphatidylcholine; PMD percent mammographic density; Q quartile; SM sphingomyelin
  2. 1Means were adjusted for age, BMI, age at menarche, family history of cancer, history of benign breast disease, use of oral contraceptive, number of full-term pregnancies, age at first full-term pregnancy, breastfeeding, alcohol intake, smoking status, socioeconomic status, and physical activity
  3. 2P value for test of linear trend across quartiles of metabolite, performed by assigning participants the median value in each quartile and modeling the corresponding variable as a continuous term
  4. 3P value for interaction term between residuals of log-transformed metabolites concentrations regressed on batch and dichotomized BMI (< 27.44/≥ 27.44)
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Breast Cancer Research

ISSN: 1465-542X

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