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Fig. 2 | Breast Cancer Research

Fig. 2

From: Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Fig. 2

Genome-wide analyses of 5-year breast cancer-specific survival. The Manhattan plots show the results of the unadjusted analyses (stratified by country). Results are represented as −log10 of the p value from Cox regression models (y-axis). The x-axis shows the chromosome number, where chromosome 23 represents the X chromosome. The red line represents the genome-wide significant threshold 5E−08, the blue line corresponds to the threshold 1E−05. Breast cancer patients included in the analysis in panel: a diagnosed with a ER+ tumor and treated with (any) endocrine therapy; b diagnosed with a ER− tumor and treated with (any) chemotherapy; c diagnosed with a ER+ or PR+, and HER2− tumor treated with (any) chemotherapy; d diagnosed with a ER+ or PR+, and HER2− tumor not treated with chemotherapy; e treated with tamoxifen; f treated with aromatase inhibitor; g treated with CMF-like chemotherapy; h treated with taxanes; i treated with anthracyclines

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Breast Cancer Research

ISSN: 1465-542X

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