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Table 3 Mean mammographic density phenotypes (95% confidence interval) by quintile of early adulthood dietary patterns (n = 1117)

From: Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density

Early adult pro-inflammatory dietary pattern
  Q1 (lowest inflammation) Q2 (low inflammation) Q3 (moderate inflammation) Q4 (high inflammation) Q5 (highest inflammation) ptrendd
(n = 251) (n = 232) (n = 217) (n = 228) (n = 189)
Percent mammographic density
 Model 1a 42.0 (39.7–44.3) 40.2 (37.7–42.6) 41.5 (39.1–43.9) 39.0 (36.8–41.2) 40.4 (38.0–42.8) 0.23
 Model 2b 40.6 (38.6–42.7) 40.3 (38.3–42.4) 41.4 (39.4–43.5) 40.1 (38.2–42.0) 40.7 (38.6–42.8) 0.98
 Model 3c 40.6 (38.6–42.7) 40.2 (38.2–42.2) 41.6 (39.6–43.7) 40.1 (38.2–41.9) 40.7 (38.6–42.8) 0.99
Dense area in cm2
 Model 1a 44.6 (41.6–47.6) 44.5 (40.9–48.1) 45.8 (42.6–49.0) 42.5 (39.7–45.4) 44.4 (40.5–48.4) 0.71
 Model 2b 44.6 (41.5–47.6) 44.5 (40.9–48.1) 45.8 (42.5–49.0) 42.6 (39.8–45.4) 44.4 (40.5–48.4) 0.73
 Model 3c 44.4 (41.3–47.5) 44.3 (40.7–47.9) 45.9 (42.7–49.2) 42.7 (39.9–45.4) 44.6 (40.7–48.5) 0.85
Non-dense area in cm2
 Model 1a 68.2 (62.7–73.7) 74.3 (68.2–80.3) 71.9 (66.0–77.7) 75.2 (69.3–81.1) 72.9 (66.3–79.4) 0.25
 Model 2b 72.9 (68.7–77.0) 73.8 (69.5–78.0) 71.9 (67.9–75.9) 71.3 (67.2–75.4) 71.9 (67.4–76.3) 0.57
 Model 3c 72.3 (68.2–76.4) 73.7 (69.5–77.9) 71.6 (67.5–75.6) 71.8 (67.7–75.9) 72.5 (68.1–76.8) 0.88
Early adult AHEI dietary pattern
  Q1 (least healthy) Q2 (unhealthy) Q3 (moderately healthy) Q4 (healthy) Q5 (most healthy) ptrendd
(n = 183) (n = 236) (n = 218) (n = 255) (n = 225)
Percent mammographic density
 Model 1a 39.9 (37.5–42.3) 39.9 (37.7–42.0) 42.0 (39.7–44.4) 41.4 (39.2–43.6) 39.8 (37.3–42.3) 0.83
 Model 2b 39.7 (37.8–41.6) 40.7 (38.8–42.6) 41.5 (39.5–43.5) 41.0 (39.0–43.0) 40.1 (38.1–42.2) 0.82
 Model 3c 39.7 (37.7–41.7) 40.8 (38.9–42.7) 41.8 (39.8–43.8) 40.8 (38.8–42.7) 39.9 (37.9–42.0) 0.98
Dense area in cm2
 Model 1a 42.0 (38.8–45.1) 45.0 (41.9–48.1) 44.8 (41.5–48.1) 46.2 (43.2–49.3) 43.1 (39.8–46.3) 0.68
 Model 2b 42.0 (38.8–45.1) 45.1 (42.0–48.2) 44.8 (41.5–48.1) 46.2 (43.1–49.3) 43.1 (39.8–46.3) 0.68
 Model 3c 42.2 (38.8–45.6) 45.4 (42.3–48.5) 45.2 (41.9–48.6) 45.8 (42.7–48.8) 42.6 (39.2–45.9) 0.97
Non-dense area in cm2
 Model 1a 71.5 (65.1–78.0) 75.0 (69.5–80.6) 66.9 (61.8–72.0) 72.0 (66.5–77.4) 76.2 (69.6–82.8) 0.49
 Model 2b 72.3 (68.2–76.4) 72.2 (68.4–76.0) 68.8 (65.1–72.6) 73.4 (69.6–77.3) 74.9 (70.3–79.5) 0.30
 Model 3c 72.9 (68.7–77.1) 72.4 (68.6–76.2) 68.6 (64.8–72.4) 73.4 (69.6–77.3) 74.5 (69.8–79.1) 0.52
  1. aAdjusted for early adulthood total calorie intake and age at the time of mammogram
  2. bAdditionally adjusted for BMI at the time of mammogram
  3. cAdditionally adjusted for BMI at age 18 (kg/m2; cont.), early adulthood physical activity (METs/week, quartiles), early adulthood alcohol intake (0 g/day; 0.1 to < 5 g/day; 5+ g/day), age at menarche (< 12; 12; 13; 14+ years), age at first birth (AFB) and parity combined (nulliparous; AFB < 25 years, 1–2 kids; AFB 25+ years, 1–2 kids; AFB any age, 3+ kids), biopsy-confirmed benign breast disease (yes; no), first-degree family history of breast cancer (yes; no)
  4. dTrend test is based on the median of the category