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Table 3 Mean mammographic density phenotypes (95% confidence interval) by quintile of early adulthood dietary patterns (n = 1117)

From: Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density

Early adult pro-inflammatory dietary pattern

 

Q1 (lowest inflammation)

Q2 (low inflammation)

Q3 (moderate inflammation)

Q4 (high inflammation)

Q5 (highest inflammation)

ptrendd

(n = 251)

(n = 232)

(n = 217)

(n = 228)

(n = 189)

Percent mammographic density

 Model 1a

42.0 (39.7–44.3)

40.2 (37.7–42.6)

41.5 (39.1–43.9)

39.0 (36.8–41.2)

40.4 (38.0–42.8)

0.23

 Model 2b

40.6 (38.6–42.7)

40.3 (38.3–42.4)

41.4 (39.4–43.5)

40.1 (38.2–42.0)

40.7 (38.6–42.8)

0.98

 Model 3c

40.6 (38.6–42.7)

40.2 (38.2–42.2)

41.6 (39.6–43.7)

40.1 (38.2–41.9)

40.7 (38.6–42.8)

0.99

Dense area in cm2

 Model 1a

44.6 (41.6–47.6)

44.5 (40.9–48.1)

45.8 (42.6–49.0)

42.5 (39.7–45.4)

44.4 (40.5–48.4)

0.71

 Model 2b

44.6 (41.5–47.6)

44.5 (40.9–48.1)

45.8 (42.5–49.0)

42.6 (39.8–45.4)

44.4 (40.5–48.4)

0.73

 Model 3c

44.4 (41.3–47.5)

44.3 (40.7–47.9)

45.9 (42.7–49.2)

42.7 (39.9–45.4)

44.6 (40.7–48.5)

0.85

Non-dense area in cm2

 Model 1a

68.2 (62.7–73.7)

74.3 (68.2–80.3)

71.9 (66.0–77.7)

75.2 (69.3–81.1)

72.9 (66.3–79.4)

0.25

 Model 2b

72.9 (68.7–77.0)

73.8 (69.5–78.0)

71.9 (67.9–75.9)

71.3 (67.2–75.4)

71.9 (67.4–76.3)

0.57

 Model 3c

72.3 (68.2–76.4)

73.7 (69.5–77.9)

71.6 (67.5–75.6)

71.8 (67.7–75.9)

72.5 (68.1–76.8)

0.88

Early adult AHEI dietary pattern

 

Q1 (least healthy)

Q2 (unhealthy)

Q3 (moderately healthy)

Q4 (healthy)

Q5 (most healthy)

ptrendd

(n = 183)

(n = 236)

(n = 218)

(n = 255)

(n = 225)

Percent mammographic density

 Model 1a

39.9 (37.5–42.3)

39.9 (37.7–42.0)

42.0 (39.7–44.4)

41.4 (39.2–43.6)

39.8 (37.3–42.3)

0.83

 Model 2b

39.7 (37.8–41.6)

40.7 (38.8–42.6)

41.5 (39.5–43.5)

41.0 (39.0–43.0)

40.1 (38.1–42.2)

0.82

 Model 3c

39.7 (37.7–41.7)

40.8 (38.9–42.7)

41.8 (39.8–43.8)

40.8 (38.8–42.7)

39.9 (37.9–42.0)

0.98

Dense area in cm2

 Model 1a

42.0 (38.8–45.1)

45.0 (41.9–48.1)

44.8 (41.5–48.1)

46.2 (43.2–49.3)

43.1 (39.8–46.3)

0.68

 Model 2b

42.0 (38.8–45.1)

45.1 (42.0–48.2)

44.8 (41.5–48.1)

46.2 (43.1–49.3)

43.1 (39.8–46.3)

0.68

 Model 3c

42.2 (38.8–45.6)

45.4 (42.3–48.5)

45.2 (41.9–48.6)

45.8 (42.7–48.8)

42.6 (39.2–45.9)

0.97

Non-dense area in cm2

 Model 1a

71.5 (65.1–78.0)

75.0 (69.5–80.6)

66.9 (61.8–72.0)

72.0 (66.5–77.4)

76.2 (69.6–82.8)

0.49

 Model 2b

72.3 (68.2–76.4)

72.2 (68.4–76.0)

68.8 (65.1–72.6)

73.4 (69.6–77.3)

74.9 (70.3–79.5)

0.30

 Model 3c

72.9 (68.7–77.1)

72.4 (68.6–76.2)

68.6 (64.8–72.4)

73.4 (69.6–77.3)

74.5 (69.8–79.1)

0.52

  1. aAdjusted for early adulthood total calorie intake and age at the time of mammogram
  2. bAdditionally adjusted for BMI at the time of mammogram
  3. cAdditionally adjusted for BMI at age 18 (kg/m2; cont.), early adulthood physical activity (METs/week, quartiles), early adulthood alcohol intake (0 g/day; 0.1 to < 5 g/day; 5+ g/day), age at menarche (< 12; 12; 13; 14+ years), age at first birth (AFB) and parity combined (nulliparous; AFB < 25 years, 1–2 kids; AFB 25+ years, 1–2 kids; AFB any age, 3+ kids), biopsy-confirmed benign breast disease (yes; no), first-degree family history of breast cancer (yes; no)
  4. dTrend test is based on the median of the category
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Breast Cancer Research

ISSN: 1465-542X

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