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Table 2 Age- and study site-stratified RR (95% CI) for breast cancer in China Kadoorie Biobank

From: Development and external validation of a breast cancer absolute risk prediction model in Chinese population

 

Cases

Cases/PYs

RR (95% CI)

(/100,000)

Highest education

 No formal school

339

44.64

1.00 (reference)

 Primary school

570

60.18

1.17 (1.11 to 1.23)

 Middle school

653

84.82

1.37 (1.24 to 1.51)

 High school

505

124.5

1.60 (1.39 to 1.85)

 College/university

220

165.2

1.87 (1.54 to 2.27)

BMI at age < 50 years, kg/m2

 < 18.5

21

98.83

1.00 (reference)

 18.5–23.9

357

126.42

0.95 (0.84 to 1.07)

 24.0–27.9

187

160.42

0.90 (0.71 to 1.14)

 ≥28

43

135.81

0.85 (0.60 to 1.21)

BMI at age ≥ 50 years, kg/m2

 < 18.5

36

41.07

1.00 (reference)

 18.5–23.9

642

66.66

1.25 (1.17 to 1.33)

 24.0–27.9

683

94.59

1.57 (1.38 to 1.78)

 ≥28

318

118.27

1.96 (1.62 to 2.38)

Height, cm

 < 150.2

382

51.58

1.00 (reference)

 150.2–154.1

504

66.66

1.13 (1.09 to 1.18)

 154.2–158.1

596

78.54

1.28 (1.18 to 1.39)

 ≥ 158.2

805

105.96

1.45 (1.28 to 1.65)

No. of first-degree relatives diagnosed with overall cancer

 0

1795

71.63

1.00 (reference)

 1

402

90.71

1.10 (0.99 to 1.23)

 ≥ 2

90

136.09

1.57 (1.27 to 1.95)

No. of live birth

 Nulliparous

45

112.79

1.78 (1.29 to 2.45)

 1

1067

101.84

1.66 (1.40 to 1.96)

 2

719

74.19

1.41 (1.22 to 1.62)

 ≥ 3

456

47.58

1.00 (reference)

Age at menarche, years

 < 12

187

114.7

1.52 (1.31 to 1.76)

 13–14

748

88.12

1.32 (1.20 to 1.46)

 15–16

837

74.27

1.15 (1.09 to 1.21)

 ≥ 17

515

58.77

1.00 (reference)

  1. Abbreviations: BMI body mass index, PY person-year, RRs relative risk, CI confidence interval
  2. Cox model was stratified by age at enrollment in 5-year interval (10 groups) and 10 study sites. All predictors above were included in the final model