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Table 4 Associations between BBD with and without considering parity and timing of first birth relative to BBD diagnosis and changes in mammographic breast density (percent MBD, dense area, non-dense area), EDMD

From: Benign breast disease and changes in mammographic breast density

 

Adjusted for agea, race, and BMI

Adjusted for agea, race, BMI, and MBD at first mammogram

Variables

N

Estimate

Standard error

p-value

95% CI

Estimate

Standard error

p-value

95% CI

Change in percent densityb

 BBD

67

−0.21

0.46

0.65

− 1.10, 0.69

− 0.08

0.47

0.86

− 1.00, 0.84

 No BBD

330

Ref

Ref

 No BBD, nulliparous

68

−0.40

0.39

0.30

−1.16, 0.36

−0.27

0.39

0.48

− 1.03, 0.49

 No BBD, parous

262

Ref

Ref

 BBD, nulliparous

15

−0.13

1.06

0.90

−2.20, 1.94

0.01

1.07

0.99

−2.09, 2.11

 BBD before first birth

19

0.71

0.57

0.22

−0.41, 1.83

1.03

0.59

0.08

−0.12, 2.18

 BBD after first birth

31

−1.01

0.67

0.13

−2.32, 0.29

−0.95

0.68

0.16

−2.28, 0.38

Change in dense areab

 BBD

67

−0.46

0.63

0.47

−1.70, 0.78

−0.33

0.63

0.61

−1.57, 0.91

 No BBD

330

Ref

Ref

 No BBD, nulliparous

68

−0.21

0.46

0.65

−1.10, 0.69

−0.13

0.45

0.77

−1.01, 0.75

 No BBD, parous

262

Ref

Ref

 BBD, nulliparous

15

−0.33

1.32

0.80

−2.92, 2.25

−0.07

1.34

0.96

−2.70, 2.57

 BBD before first birth

19

0.38

0.61

0.53

−0.82, 1.58

0.48

0.56

0.39

−0.62, 1.58

 BBD after first birth

31

−1.45

1.05

0.17

−3.51, 0.60

−1.30

1.06

0.22

−3.37, 0.77

Change in non-dense areab

 BBD

67

1.94

0.95

0.04

0.08, 3.80

1.71

1.02

0.09

−0.29, 3.71

 No BBD

330

Ref

Ref

 No BBD, nulliparous

68

1.08

1.15

0.35

−1.17, 3.33

0.92

1.09

0.40

−1.23, 3.07

 No BBD, parous

262

Ref

Ref

 BBD, nulliparous

15

2.21

2.00

0.27

−1.72, 6.13

1.83

2.09

0.38

−2.27, 5.93

 BBD before first birth

19

−0.29

0.69

0.68

−1.64, 1.06

− 0.68

0.68

0.31

−2.01, 0.65

 BBD after first birth

31

3.48

1.59

0.03

0.37, 6.59

3.43

1.71

0.05

0.08, 6.79

  1. aAge at first mammogram
  2. bChange in MBD was calculated as MBD at last mammogram minus MBD at first mammogram divided by age at last mammogram minus age at first mammogram