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Table 4 Associations between BBD with and without considering parity and timing of first birth relative to BBD diagnosis and changes in mammographic breast density (percent MBD, dense area, non-dense area), EDMD

From: Benign breast disease and changes in mammographic breast density

  Adjusted for agea, race, and BMI Adjusted for agea, race, BMI, and MBD at first mammogram
Variables N Estimate Standard error p-value 95% CI Estimate Standard error p-value 95% CI
Change in percent densityb
 BBD 67 −0.21 0.46 0.65 − 1.10, 0.69 − 0.08 0.47 0.86 − 1.00, 0.84
 No BBD 330 Ref Ref
 No BBD, nulliparous 68 −0.40 0.39 0.30 −1.16, 0.36 −0.27 0.39 0.48 − 1.03, 0.49
 No BBD, parous 262 Ref Ref
 BBD, nulliparous 15 −0.13 1.06 0.90 −2.20, 1.94 0.01 1.07 0.99 −2.09, 2.11
 BBD before first birth 19 0.71 0.57 0.22 −0.41, 1.83 1.03 0.59 0.08 −0.12, 2.18
 BBD after first birth 31 −1.01 0.67 0.13 −2.32, 0.29 −0.95 0.68 0.16 −2.28, 0.38
Change in dense areab
 BBD 67 −0.46 0.63 0.47 −1.70, 0.78 −0.33 0.63 0.61 −1.57, 0.91
 No BBD 330 Ref Ref
 No BBD, nulliparous 68 −0.21 0.46 0.65 −1.10, 0.69 −0.13 0.45 0.77 −1.01, 0.75
 No BBD, parous 262 Ref Ref
 BBD, nulliparous 15 −0.33 1.32 0.80 −2.92, 2.25 −0.07 1.34 0.96 −2.70, 2.57
 BBD before first birth 19 0.38 0.61 0.53 −0.82, 1.58 0.48 0.56 0.39 −0.62, 1.58
 BBD after first birth 31 −1.45 1.05 0.17 −3.51, 0.60 −1.30 1.06 0.22 −3.37, 0.77
Change in non-dense areab
 BBD 67 1.94 0.95 0.04 0.08, 3.80 1.71 1.02 0.09 −0.29, 3.71
 No BBD 330 Ref Ref
 No BBD, nulliparous 68 1.08 1.15 0.35 −1.17, 3.33 0.92 1.09 0.40 −1.23, 3.07
 No BBD, parous 262 Ref Ref
 BBD, nulliparous 15 2.21 2.00 0.27 −1.72, 6.13 1.83 2.09 0.38 −2.27, 5.93
 BBD before first birth 19 −0.29 0.69 0.68 −1.64, 1.06 − 0.68 0.68 0.31 −2.01, 0.65
 BBD after first birth 31 3.48 1.59 0.03 0.37, 6.59 3.43 1.71 0.05 0.08, 6.79
  1. aAge at first mammogram
  2. bChange in MBD was calculated as MBD at last mammogram minus MBD at first mammogram divided by age at last mammogram minus age at first mammogram