Table 4 Mediation analysis of the effect of current versus never use (reference category) of menopausal hormone therapy on breast cancer risk, overall and by ER and PR status. The table reports the OR and 95% confidence intervals from the unconditional logistic models adjusted for age at mammogram and the matching variables (reference age, year of birth and menopausal status at baseline)
All OR (95% CI) | ER+ or PR+ OR (95% CI) | ER− and PR− OR (95% CI) | |
|---|---|---|---|
NCA = 196/NCO = 196 | NCA = 150/NCO = 150 | NCA = 22/NCO = 22 | |
Total effect | 1.46 (0.92 to 2.41) | 1.58 (0.93 to 2.64) | 0.63 (0.11 to 2.61) |
Average direct effect | 1.37 (0.85 to 2.18) | 1.44 (0.85 to 2.34) | 0.61 (0.10 to 2.48) |
Average joint mediated effect | 1.07 (0.92 to 1.25) | 1.10 (0.93 to 1.37) | 1.00 (0.48 to 2.52) |
Average mediated effect by PMD | 1.20 (1.06 to 1.41) | 1.22 (1.06 to 1.52) | 1.10 (0.61 to 2.63) |
Average mediated effect by BMI | 0.90 (0.78 to 0.98) | 0.91 (0.78 to 0.99) | 1.00 (0.49 to 1.40) |