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Table 4 Mediation analysis of the effect of current versus never use (reference category) of menopausal hormone therapy on breast cancer risk, overall and by ER and PR status. The table reports the OR and 95% confidence intervals from the unconditional logistic models adjusted for age at mammogram and the matching variables (reference age, year of birth and menopausal status at baseline)

From: Association between menopausal hormone therapy, mammographic density and breast cancer risk: results from the E3N cohort study

  All
OR (95% CI)
ER+ or PR+
OR (95% CI)
ER− and PR−
OR (95% CI)
NCA = 196/NCO = 196 NCA = 150/NCO = 150 NCA = 22/NCO = 22
Total effect 1.46 (0.92 to 2.41) 1.58 (0.93 to 2.64) 0.63 (0.11 to 2.61)
Average direct effect 1.37 (0.85 to 2.18) 1.44 (0.85 to 2.34) 0.61 (0.10 to 2.48)
Average joint mediated effect 1.07 (0.92 to 1.25) 1.10 (0.93 to 1.37) 1.00 (0.48 to 2.52)
Average mediated effect by PMD 1.20 (1.06 to 1.41) 1.22 (1.06 to 1.52) 1.10 (0.61 to 2.63)
Average mediated effect by BMI 0.90 (0.78 to 0.98) 0.91 (0.78 to 0.99) 1.00 (0.49 to 1.40)
  1. Mediation analysis evaluating the direct and indirect effect of current versus never use of MHT on breast cancer risk, overall and by ER and PR status in presence of PMD and BMI, correlated mediators