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Table 3 Associations of breast cancer risk with summary phthalate exposures in all women and by race/ethnicity

From: Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study

Summary phthalate All
(1032 ca/1030 co)
Whites
(274 ca/273 co)
Japanese Americans
(478 ca/478 co)
Native Hawaiians
(155 ca/154 co)
African Americans and Latinos
(125 ca/125 co)
Phet raceb
OR (95% CI)a OR (95% CI)a OR (95% CI)a OR (95% CI)a OR (95% CI)a  
∑DEHPc
 ≤ 63.21 1.00 1.00 1.00 1.00 1.00  
 63.21–133.05 1.03 (0.82–1.27) 0.83 (0.54–1.29) 0.99 (0.72–1.36) 1.29 (0.75–2.22) 1.38 (0.71–2.69)  
 > 133.05 0.93 (0.73–1.17) 0.74 (0.47–1.18) 0.97 (0.68–1.36) 1.49 (0.79–2.79) 0.76 (0.38–1.52)  
P trendd 0.61 0.20 0.85 0.21 0.57 0.43
∑HMWPc
 ≤ 78.13 1.00 1.00 1.00 1.00 1.00  
 > 78.13–149.24 0.95 (0.77–1.18) 0.73 (0.47–1.14) 0.95 (0.70–1.30) 1.18 (0.68–2.04) 1.29 (0.68–2.43)  
 > 149.24 0.99 (0.79–1.25) 0.75 (0.46–1.20) 1.03 (0.74–1.44) 1.76 (0.94–3.29) 0.78 (0.40–1.50)  
P trendd 0.87 0.18 0.93 0.10 0.62 0.32
∑LMWPc
 ≤ 64.0 1.00 1.00 1.00 1.00 1.00  
 > 64.0–145.29 1.15 (0.92–1.44) 1.05 (0.66–1.67) 1.13 (0.82–1.55) 1.38 (0.81–2.38) 0.88 (0.35–2.23)  
 > 145.29 1.18 (0.93–1.50) 1.10 (0.68–1.78) 1.24 (0.87–1.77) 1.64 (0.89–3.04) 0.66 (0.29–1.53)  
P trendd 0.16 0.70 0.23 0.10 0.24 0.44
∑LMHMPAc
 ≤ 226.38 1.00 1.00 1.00 1.00 1.00  
 > 226.38–442.34 1.03 (0.83–1.29) 0.87 (0.56–1.36) 0.84 (0.62–1.17) 2.43 (1.33–4.44) 1.01 (0.51–1.98)  
 > 442.34 1.23 (0.96–1.58) 1.00 (0.62–1.62) 1.19 (0.82–1.73) 2.66 (1.39–5.12) 0.73 (0.34–1.57)  
P trendd 0.15 0.96 0.65 0.001 0.47 0.05
∑LMHMmolarc
 ≤ 0.581 1.00 1.00 1.00 1.00 1.00  
 > 0.581–1.143 1.02 (0.82–1.28) 1.38 (0.87–2.21) 0.70 (0.51–0.97) 1.53 (0.86–2.71) 1.39 (0.68–2.85)  
 > 1.143 1.18 (0.92–1.50) 1.33 (0.80–2.20) 1.03 (0.72–1.47) 1.89 (1.06–3.38) 0.83 (0.39–1.77)  
P trendd 0.23 0.25 0.78 0.03 0.64 0.18
  1. aConditional logistic regression with the matched sets as strata and adjusted for education, number of children, age at menarche, menopausal status, BMI at urine collection, neighborhood socioeconomic status at urine collection, smoking, alcohol intake, and Mediterranean energy adjusted total score
  2. bP heterogeneity (race) df = 4
  3. cDEHP, sum of MEHP, MEHHP, MEOHP, and MECPP; HMWP, sum of high molecular weight phthalates (MBzP, DEHP metabolites, and MECP); LMWP, sum of low molecular weight phthalates (MMP, MEP, MBP, MiBP); LMHMPA, sum of LMWP, HMWP, and PA; and LMHM molar ratios were calculated by dividing the concentration of each metabolite by its molecular weight to obtain the molar equivalent (micromoles per liter) and then summed the concentrations in micromoles per liter to get total micromoles per liter of metabolites
  4. dP trend (log phthalate) df = 1