Table 2 Assessment of histological tumour type and F4/80- and CCR7-positive staining of DMBA-induced tumours in doxycycline-treated Cfms-rtTA, TetO-TbrII and Cfms-TbrII mice. Histology was assessed in H&E-stained tissue sections and classified as adenocarcinoma (solid or glandular), carcinosarcoma, adenosquamous carcinoma and adenoma/mammary intraepithelial neoplasia (MIN). F4/80 and CCR7 immunohistochmistry staining was classified as either none/minimal or scattered. The number of tumours of each type for each genotype is presented, and the percent and the number of those tumours exhibiting F4/80- or CCR7-positive staining classified as scattered are shown. In some cases, tumour staining was not assessed (N/A) as there was no tumour present
| Â | Cfms-rtTA | TetO-TgfbrII | Cfms-TbrII | |||
|---|---|---|---|---|---|---|
F4/80 | CCR7 | F4/80 | CCR7 | F4/80 | CCR7 | |
Adenocarcinoma (solid) | 3 | 5 | 0 | |||
 % (N) | 33 (1) | 67 (2) | 0 (0) | 20 (1) | N/A | N/A |
Adenocarcinoma (glandular) | 1 | 0 | 4 | |||
 % (N) | 0 (0) | 0 (0) | N/A | N/A | 50 (2) | 0 (0) |
Carcinosarcoma | 2 | 3 | 2 | |||
 % (N) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 50 (1) | 0 (0) |
Adenosquamous carcinoma | 3 | 3 | 0 | |||
 % (N) | 67 (2) | 0 (0) | 67 (2) | 0 (0) | N/A | N/A |
Adenoma/MIN | 1 | 1 | 0 | |||
 % (N) | 100 (1) | 0 (0) | 100 (1) | 0 (0) | N/A | N/A |
Total | 10 | 12 | 6 | |||
 % (N) | 40 (4) | 20 (2) | 25 (3) | 8 (1) | 50 (3) | 0 (0) |