Fig. 2

Temporal trends in SIRs for contralateral breast cancer overall and excluding women with contralateral prophylactic mastectomy (CPM) among 1-year survivors of a first primary breast cancer in 12 SEER registries, 1992–2016. Estimates for contralateral breast cancer by calendar period of first breast cancer diagnosis are a overall, and according to b age at first breast cancer diagnosis, c ER status of first breast cancer, d after ER-positive breast cancer by age at first diagnosis, and e after ER-negative breast cancer by age at first diagnosis. Gray dashed lines indicate exclusion of CPM