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Table 5 Associations between changing slope in body mass index and clinical outcomes: subgroup analysis

From: Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients

 

Overall survival

Breast cancer-specific survival

Disease-free survival

Events/persons

HR (95% CI)*

P

Events/persons

HR (95% CI)*

P

Events/persons

HR (95% CI)*

P

In Whites

 Loss > 0.5 kg/m2/year

40/285

2.22 (1.31–3.75)

0.003

20/285

1.75 (0.86–3.55)

0.12

40/266

2.04 (1.21–3.44)

0.008

 Stable (≤ 0.5 kg/m2/year)

30/744

1.0 (ref.)

 

18/744

1.0 (ref.)

 

31/706

1.0 (ref.)

 

 Gain > 0.5 kg/m2/year

25/372

1.41 (0.79–2.51)

0.25

15/372

1.02 (0.47–2.19)

0.96

22/348

1.33 (0.75–2.38)

0.33

In Blacks

 Loss > 0.5 kg/m2/year

93/280

2.80 (1.86–4.22)

< 0.001

46/280

4.27 (2.22–8.21)

< 0.001

83/254

2.29 (1.50–3.49)

< 0.001

 Stable (≤ 0.5 kg/m2/year)

42/437

1.0 (ref.)

 

14/437

1.0 (ref.)

 

46/409

1.0 (ref.)

 

 Gain > 0.5 kg/m2/year

36/219

1.72 (1.05–2.84)

0.033

23/219

2.48 (1.21–5.08)

0.013

37/205

1.78 (1.08–2.92)

0.023

Test for interaction

  

0.77

  

0.14

  

0.76

In women with normal weight at diagnosis

 Loss > 0.5 kg/m2/year

15/77

1.92 (0.91–4.05)

0.086

8/77

2.73 (0.90–8.31)

0.077

15/74

1.91 (0.87–4.16)

0.11

 Stable (≤ 0.5 kg/m2/year)

22/445

1.0 (ref.)

 

10/445

1.0 (ref.)

 

18/427

1.0 (ref.)

 

 Gain > 0.5 kg/m2/year

10/182

0.99 (0.45–2.16)

0.97

6/182

1.33 (0.44–4.03)

0.61

11/176

1.16 (0.53–2.55)

0.71

In women with overweight/obese at diagnosis

 Loss > 0.5 kg/m2/year

85/414

3.07 (1.96–4.80)

< 0.001

46/414

3.08 (1.62–5.87)

0.001

76/389

2.21 (1.41–3.45)

< 0.001

 Stable (≤ 0.5 kg/m2/year)

36/647

1.0 (ref.)

 

16/647

1.0 (ref.)

 

44/613

1.0 (ref.)

 

 Gain > 0.5 kg/m2/year

30/318

1.96 (1.14–3.37)

0.015

16/318

1.47 (0.69–3.12)

0.32

27/304

1.56 (0.90–2.71)

0.11

Test for interaction

  

0.32

  

0.98

  

0.83

In women ages < 50

 Loss > 0.5 kg/m2/year

24/135

3.94 (1.87–8.30)

< 0.001

17/135

3.40 (1.40–8.25)

0.007

21/115

4.48 (2.05–9.79)

< 0.001

 Stable (≤ 0.5 kg/m2/year)

13/407

1.0 (ref.)

 

10/407

1.0 (ref.)

 

11/372

1.0 (ref.)

 

 Gain > 0.5 kg/m2/year

18/281

1.58 (0.74–3.39)

0.238

16/281

1.64 (0.69–3.90)

0.27

16/259

1.65 (0.74–3.67)

0.22

In women ages ≥ 50

 Loss > 0.5 kg/m2/year

113/467

2.38 (1.67–3.38)

< 0.001

52/467

2.95 (1.73–5.04)

< 0.001

104/439

1.83 (1.28–2.62)

0.001

 Stable (≤ 0.5 kg/m2/year)

63/882

1.0 (ref.)

 

25/882

1.0 (ref.)

 

70/845

1.0 (ref.)

 

 Gain > 0.5 kg/m2/year

45/350

1.68 (1.09–2.59)

0.019

24/350

1.83 (0.98–3.43)

0.057

45/333

1.59 (1.04–2.43)

0.032

Test for interaction

  

0.26

  

0.86

  

0.043

  1. *Adjusted for age, race, Carlson comorbidity index, tumor stage, histologic grade, molecular subtype, radiotherapy, hormonal therapy, and chemotherapy in delayed entry Cox models
  2. Abbreviations: BMI body mass index, HR hazard ratio, CI confidence intervals
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Breast Cancer Research

ISSN: 1465-542X

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