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Table 5 Associations between changing slope in body mass index and clinical outcomes: subgroup analysis

From: Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients

  Overall survival Breast cancer-specific survival Disease-free survival
Events/persons HR (95% CI)* P Events/persons HR (95% CI)* P Events/persons HR (95% CI)* P
In Whites
 Loss > 0.5 kg/m2/year 40/285 2.22 (1.31–3.75) 0.003 20/285 1.75 (0.86–3.55) 0.12 40/266 2.04 (1.21–3.44) 0.008
 Stable (≤ 0.5 kg/m2/year) 30/744 1.0 (ref.)   18/744 1.0 (ref.)   31/706 1.0 (ref.)  
 Gain > 0.5 kg/m2/year 25/372 1.41 (0.79–2.51) 0.25 15/372 1.02 (0.47–2.19) 0.96 22/348 1.33 (0.75–2.38) 0.33
In Blacks
 Loss > 0.5 kg/m2/year 93/280 2.80 (1.86–4.22) < 0.001 46/280 4.27 (2.22–8.21) < 0.001 83/254 2.29 (1.50–3.49) < 0.001
 Stable (≤ 0.5 kg/m2/year) 42/437 1.0 (ref.)   14/437 1.0 (ref.)   46/409 1.0 (ref.)  
 Gain > 0.5 kg/m2/year 36/219 1.72 (1.05–2.84) 0.033 23/219 2.48 (1.21–5.08) 0.013 37/205 1.78 (1.08–2.92) 0.023
Test for interaction    0.77    0.14    0.76
In women with normal weight at diagnosis
 Loss > 0.5 kg/m2/year 15/77 1.92 (0.91–4.05) 0.086 8/77 2.73 (0.90–8.31) 0.077 15/74 1.91 (0.87–4.16) 0.11
 Stable (≤ 0.5 kg/m2/year) 22/445 1.0 (ref.)   10/445 1.0 (ref.)   18/427 1.0 (ref.)  
 Gain > 0.5 kg/m2/year 10/182 0.99 (0.45–2.16) 0.97 6/182 1.33 (0.44–4.03) 0.61 11/176 1.16 (0.53–2.55) 0.71
In women with overweight/obese at diagnosis
 Loss > 0.5 kg/m2/year 85/414 3.07 (1.96–4.80) < 0.001 46/414 3.08 (1.62–5.87) 0.001 76/389 2.21 (1.41–3.45) < 0.001
 Stable (≤ 0.5 kg/m2/year) 36/647 1.0 (ref.)   16/647 1.0 (ref.)   44/613 1.0 (ref.)  
 Gain > 0.5 kg/m2/year 30/318 1.96 (1.14–3.37) 0.015 16/318 1.47 (0.69–3.12) 0.32 27/304 1.56 (0.90–2.71) 0.11
Test for interaction    0.32    0.98    0.83
In women ages < 50
 Loss > 0.5 kg/m2/year 24/135 3.94 (1.87–8.30) < 0.001 17/135 3.40 (1.40–8.25) 0.007 21/115 4.48 (2.05–9.79) < 0.001
 Stable (≤ 0.5 kg/m2/year) 13/407 1.0 (ref.)   10/407 1.0 (ref.)   11/372 1.0 (ref.)  
 Gain > 0.5 kg/m2/year 18/281 1.58 (0.74–3.39) 0.238 16/281 1.64 (0.69–3.90) 0.27 16/259 1.65 (0.74–3.67) 0.22
In women ages ≥ 50
 Loss > 0.5 kg/m2/year 113/467 2.38 (1.67–3.38) < 0.001 52/467 2.95 (1.73–5.04) < 0.001 104/439 1.83 (1.28–2.62) 0.001
 Stable (≤ 0.5 kg/m2/year) 63/882 1.0 (ref.)   25/882 1.0 (ref.)   70/845 1.0 (ref.)  
 Gain > 0.5 kg/m2/year 45/350 1.68 (1.09–2.59) 0.019 24/350 1.83 (0.98–3.43) 0.057 45/333 1.59 (1.04–2.43) 0.032
Test for interaction    0.26    0.86    0.043
  1. *Adjusted for age, race, Carlson comorbidity index, tumor stage, histologic grade, molecular subtype, radiotherapy, hormonal therapy, and chemotherapy in delayed entry Cox models
  2. Abbreviations: BMI body mass index, HR hazard ratio, CI confidence intervals