Table 1 Association between infiltrating immune cell counts (IICCs) in women biopsied for benign breast disease and risk of subsequent invasive breast cancer risk
From: Infiltrating immune cells in benign breast disease and risk of subsequent invasive breast cancer
IICCs in normal tissue (%) | IICCs in BBD lesion (%) | |||||||
|---|---|---|---|---|---|---|---|---|
Per 5% increase | < 5 | ≥ 5 | Missing | Per 5% increase | < 5 | ≥ 5 | Missing | |
Overall | ||||||||
Cases/controls | 424/422 | 84/81 | 11/17 | 326/335 | 93/82 | 100/103 | ||
Age-adjusted OR | 1.05 (0.96–1.15) | 1.00 | 1.04 (0.74–1.45) | – | 1.04 (0.94–1.16) | 1.00 | 1.16 (0.83–1.62) | – |
Multivariable-adjusted ORa | 1.05 (0.96–1.16) | 1.00 | 1.04 (0.74–1.48) | – | 1.06 (0.96–1.18) | 1.00 | 1.11 (0.79–1.58) | – |
Menopausal status | ||||||||
Premenopausal | ||||||||
Cases/controls | 165/142 | 41/38 | 3/7 | 131/122 | 42/23 | 36/42 | ||
Age-adjusted OR | 1.02 (0.91–1.13) | 1.00 | 0.95 (0.58–1.56) | – | 1.17 (0.97–1.41) | 1.00 | 1.73 (0.98–3.05) | – |
Multivariable-adjusted OR | 1.01 (0.90–1.14) | 1.00 | 0.95 (0.56–1.63) | – | 1.16 (0.96–1.40) | 1.00 | 1.52 (0.83–2.79) | – |
Postmenopausal | ||||||||
Cases/controls | 178/206 | 32/29 | 4/9 | 132/156 | 37/46 | 45/42 | ||
Age-adjusted OR | 1.37 (1.01–1.85) | 1.00 | 1.28 (0.75–2.21) | – | 0.96 (0.82–1.13) | 1.00 | 0.94 (0.57–1.54) | – |
Multivariable-adjusted OR | 1.34 (0.99–1.83) | 1.00 | 1.19 (0.67–2.09) | – | 0.99 (0.83–1.19) | 1.00 | 0.98 (0.58–1.66) | – |
P for heterogeneityb | 0.56 | 0.23 | ||||||
BBD | ||||||||
Non-proliferative | ||||||||
Cases/controls | 59/78 | 11/17 | 2/4 | 27/46 | 8/10 | 37/43 | ||
Age-adjusted OR | 1.03 (0.85–1.25) | 1.00 | 1.00 (0.98–1.01) | – | 1.07 (0.79–1.44) | 1.00 | 1.40 (0.40–4.00) | – |
Multivariable-adjusted ORc | 1.12 (0.90–1.39) | 1.00 | 1.15 (0.45–2.95) | – | 1.15 (0.69–1.91) | 1.00 | 1.43 (0.42–4.82) | – |
Proliferative | ||||||||
Cases/controls | 356/329 | 68/62 | 9/12 | 298/284 | 85/71 | 50/48 | ||
Age-adjusted OR | 1.06 (0.95–1.17) | 1.00 | 1.00 (0.99–1.01) | – | 1.05 (0.94–1.18) | 1.00 | 1.15 (0.80–1.63) | – |
Multivariable-adjusted OR | 1.03 (0.93–1.15) | 1.00 | 0.94 (0.64–1.39) | – | 1.06 (0.95–1.19) | 1.00 | 1.07 (0.74–1.55) | – |
P for heterogeneityb | 0.88 | 0.83 | ||||||
BMI | ||||||||
18.5–24.9 kg/m2 | ||||||||
Cases/controls | 170/166 | 36/31 | 2/6 | 128/119 | 41/34 | 39/50 | ||
Age-adjusted OR | 1.02 (0.87–1.19) | 1.00 | 1.10 (0.65–1.88) | – | 1.03 (0.88–1.22) | 1.00 | 1.13 (0.67–1.90) | – |
Multivariable-adjusted OR | 1.10 (0.93–1.30) | 1.00 | 1.23 (0.70–2.16) | – | 1.10 (0.92–1.33) | 1.00 | 1.18 (0.67–2.07) | – |
≥ 25.0 kg/m2 | ||||||||
Cases/controls | 208/210 | 37/38 | 7/6 | 165/166 | 35/45 | 52/43 | ||
Age-adjusted OR | 1.05 (0.92–1.20) | 1.00 | 1.02 (0.62–1.68) | – | 0.95 (0.83–1.10) | 1.00 | 0.74 (0.67–1.22) | – |
Multivariable-adjusted OR | 1.00 (0.88–1.15) | 1.00 | 0.91 (0.54–1.53) | – | 1.00 (0.86–1.17) | 1.00 | 0.68 (0.40–1.14) | – |
P for heterogeneityb | 0.45 | 0.23 | ||||||
Cigarette smoking | ||||||||
No | ||||||||
Cases/controls | 149/171 | 35/31 | 3/4 | 113/128 | 34/32 | 40/46 | ||
Age-adjusted OR | 1.03 (0.85–1.25) | 1.00 | 1.40 (0.82–2.40) | – | 0.95 (0.78–1.14) | 1.00 | 1.15 (0.66–1.99) | – |
Multivariable-adjusted OR | 1.12 (0.90–1.39) | 1.00 | 1.49 (0.85–2.61) | – | 0.92 (0.76–1.13) | 1.00 | 1.09 (0.61–1.97) | – |
Yes | ||||||||
Cases/controls | 173/185 | 25/32 | 5/5 | 139/155 | 32/30 | 32/37 | ||
Age-adjusted OR | 1.06 (0.95–1.17) | 1.00 | 0.82 (0.47–1.45) | – | 1.06 (0.92–1.22) | 1.00 | 1.20 (0.69–2.08) | – |
Multivariable-adjusted OR | 1.03 (0.93–1.15) | 1.00 | 0.73 (0.40–1.35) | – | 1.13 (0.97–1.32) | 1.00 | 1.29 (0.72–2.32) | – |
P for heterogeneityb | 0.12 | 0.86 | ||||||