Fig. 1

Breast cancer-specific survival proportions, hazard rates and adjusted hazard ratios by IHC subtype and grade. Legend: Survival proportions (panels a–f), hazard rates (panels g–l) and adjusted hazard ratios (panels m–r) including n = 19,220 women with known information on ER, PR, HER2, grade, TNM stage and surgery type. Numbers at risk at start: ER+PR+HER2− n = 3497 (grade I), n = 6605 (grade II), n = 1789 (grade III); ER+PR−HER2− n = 597 (grade I), n = 1399 (grade II), n = 717 (grade III); ER+PR+HER2+ n = 637 (grade II), n = 564 (grade III); ER+PR−HER2+ n = 318 (grade II), n = 369 (grade III); HER2pos n = 235 (grade II), n = 688 (grade III); TNBC n = 320 (grade II), n = 1485 (grade III). Logrank tests of survival differences by grade: ER+PR+HER2− p < 0.001, ER+PR−HER2− p < 0.001, ER+PR+HER2+ p = 0.7013, ER+PR−HER2+ p = 0.0836, HER2pos p = 0.1466, TNBC p = 0.6230. Hazard rate curves only plotted until last event in each group. Hazard ratios adjusted for age and year at diagnosis, subtype × grade interaction, TNM stage, surgery type and follow-up. N = 19,220. Estimates of HRs are given in Additional file 9