Fig. 4
From: Molecular analyses of triple-negative breast cancer in the young and elderly
Copy number alterations versus age at diagnosis in TNBC. a Copy number landscape of HRDetect-high patients < 50 years at diagnosis versus > 70 years at diagnosis. b Difference in amplification frequency of CCND1, CCNE1, EGFR, and MCL1 with age groups when analyzed in the total SCAN-B cohort. Two-sided p values calculated using chi-square test for trends in proportions. c Difference in mutation frequency of PIK3CA and TP53 with age groups when analyzed in the total SCAN-B cohort. Two-sided p values calculated using chi-square test for trends in proportions. d Proportions of amplified cases for CCND1, CCNE1, EGFR, and MCL1 according to HRDetect classification. e Proportions of mutated cases for PIK3CA and TP53 according to HRDetect (left), PAM50 (center), and TNBCtype (right) classifications. For age group definitions, “[” equals ≥, “)” equals <, and “]” equals ≤ for the value specified next to it