Fig. 5
Leronlimab blocks breast cancer metastasis in mice (a). The mice were divided randomly into 4 groups (control, leronlimab, maraviroc, and vicriviroc). MDA-MB-231 cells stably transfected with Luc2-GFP were injected into the mice via the tail vein. The mice in each group were pretreated 1 day before injection with breast cancer cells. The volume of the metastatic tumor formed in the lung was determined by bioluminescence imaging. The bioluminescence images of representative mice from the control, leronlimab, and maraviroc groups are shown in b. The quantitative analysis of tumor size in each group is shown in c. The size of tumors is defined by photon flux (× 109 p/s/cm2/sr). The data was show as mean ± SE. Leronlimab pretreatment decreased breast cancer tumor metastasis to the lung