Table 1 Prospective cohort of BRCA1 and BRCA2 mutation carriers
IBCCS studies | BRCA1 mutation carriers | BRCA2 mutation carriers | ||||||
|---|---|---|---|---|---|---|---|---|
Number of women | FUP time mean, years (sd) | BC, N | Mean age BC diagnosis, years | Number of women | FUP time mean, years (sd) | BC, N | Mean age BC diagnosis, years | |
EMBRACE | 471 | 4.4 (3.0) | 41 | 45.4 | 478 | 3.9 (2.5) | 42 | 48.2 |
GENEPSO | 486 | 3.6 (2.4) | 46 | 45.8 | 325 | 3.2 (1.9) | 18 | 48.8 |
HEBON | 242 | 7.2 (3.6) | 40 | 47.6 | 75 | 5.9 (2.8) | 4 | 47.3 |
kConFab | 325 | 6.7 (3.8) | 55 | 42.2 | 288 | 6.4 (3.7) | 38 | 50.5 |
BCFR | 327 | 7.7 (4.4) | 50 | 47.1 | 255 | 7.5 (4.3) | 33 | 49.8 |
Other studiesa | 421 | 4.9 (3.2) | 37 | 41.4 | 184 | 4.3 (2.9) | 22 | 47.0 |
Total | 2272 | 5.4 (3.7) | 269 | 44.9 | 1605 | 4.9 (3.4) | 157 | 49.0 |