Fig. 3

Predicted domain structure of the proteins encoded by the PPP6R3-TENM4-NRG1 fusion. Schematic diagrams showing the major domains detected by SMART [38]. a Normal structures: a typical transmembrane NRG1 and a β3 isoform, and TENM4 (PPP6R3 contributes only untranslated sequence). At least some β3 isoforms go to the nucleus [1, 43]. b Predicted structure of fusion proteins. One EGF-repeat and the transmembrane domain of TENM4 are retained, juxtaposed to the Ig-like domain of NRG1. The chimeric protein may either include the transmembrane and cytoplasmic region of NRG1 or the short β3 terminus