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Table 1 Characteristics of female breast cancer patients in the discovery and validation sets

From: Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection

Baseline variable Discovery set Validation set
Cases Controls Cases Controls
(n = 20) (n = 20) (n = 19) (n = 41)
Sex (Female) 20 20 19 41
Mean age (years) 59.2 ± 11.4 60.1 ± 7.3 60 ± 15.4 51 ± 6.3
Suspicious mammography with negative cytology     4
Smoking status
 Never 12 19   19
 Former 3    7
 Current 4 1   11
 NA 1    4
Clinical stage
 0 Tis N0 M0     
 I T1 N0 M0 10   19  
 IIA T1 N1 M0 5    
 IIB T2 N1 M0 2    
 IIIA T0 N2 M0 3    
ER
 Positive/negative/NA 9/−/11   10/4/5  
PgR
 Positive/negative/NA 8/−/12   9/5/5  
Her2 Neu
 Positive/negative/NA 10/7/3   10/4/5  
Histologic grading
 G1/G2/G3/NA 0/8/5/7   2/12/5/0  
Molecular subtype
 Luminal/Her2-enriched/triple-negative/NA    10/3/1/5  
Comorbidities
 None reported   17   22
 Diabetes (type I or type II)     3
 Allergy     1
 Thyroid nodules     1
 Hypothyroidism   1   3
 Chronic gastritis     1
 Depressive disorder     2
 Hypertension   1   4
 Hypotension     1
 Osteoporosis     1
 Hypocholesterolemia   1   
 Epilepsy   1   
 Arthrosis     2
 Asthma     1