Fig. 7From: CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stressGraphical rendering of GRP78-dependent CRIPTO signaling driving stem-like tumor cell phenotypes. Cellular stresses that promote GRP78 re-localization to the cell surface could render such cells susceptible to CRIPTO-mediated signaling that balances growth factor-like signaling with TGF-beta pathway signaling to promote growth and plasticityBack to article page