Table 1 NeoALTTO patient characteristics by body mass index (BMI) categories
Overall (N = 454) | BMI categories | |||||
|---|---|---|---|---|---|---|
Underweight (N = 14) | Normal weight (N = 220) | Overweight (N = 137) | Obese (N = 83) | p value | ||
Median age (years) at baseline | 50 | 46 | 48 | 51 | 52 | < 0.001 |
Randomized arm, N (%) | ||||||
L | 153 (34) | 1 (7) | 83 (38) | 49 (36) | 20 (24) | 0.099 |
T | 149 (33) | 6 (43) | 71 (32) | 40 (29) | 32 (39) | |
L + T | 152 (33) | 7 (50) | 66 (30) | 48 (35) | 31 (37) | |
Clinical tumor size, N (%) | ||||||
≤ 5 cm | 274 (60) | 9 (64) | 135 (61) | 79 (58) | 51 (61) | 0.887 |
> 5 cm | 180 (40) | 5 (36) | 85 (39) | 58 (42) | 32 (39) | |
HR status, N (%) | ||||||
Negative | 223 (49) | 3 (21) | 110 (50) | 73 (53) | 37 (45) | 0.112 |
Positive | 231 (51) | 11 (79) | 110 (50) | 64 (47) | 46 (55) | |
Menopausal status, N (%) | ||||||
Post-menopausal | 189 (42) | 5 (36) | 76 (35) | 68 (50) | 40 (48) | 0.036 |
Pre-menopausal | 219 (48) | 9 (64) | 122 (55) | 53 (39) | 35 (42) | |
NA and age < 50 | 14 (3) | 0 | 9 (4) | 2 (1) | 3 (4) | |
NA and age ≥ 50 | 32 (7) | 0 | 13 (6) | 14 (10) | 5 (6) | |
Histology grade, N (%) | ||||||
G1 | 12 (3) | 1 (7) | 2 (< 1) | 5 (4) | 4 (5) | 0.121 |
G2 | 171 (38) | 8 (57) | 91 (41) | 48 (35) | 24 (29) | |
G3 | 205 (45) | 3 (21) | 101 (46) | 62 (46) | 39 (47) | |
GX | 65 (14) | 2 (14) | 26 (12) | 21 (15) | 16 (19) | |
Planned surgery, N (%) | ||||||
Conservative surgery | 130 (29) | 5 (36) | 63 (29) | 39 (28) | 23 (28) | 0.944 |
Mastectomy | 324 (71) | 9 (64) | 157 (71) | 98 (72) | 60 (72) | |
Clinical nodal status, N (%) | ||||||
N0/1 | 382 (84) | 13 (93) | 189 (86) | 112 (82) | 68 (82) | 0.531 |
≥ N2, Nx or missing | 72 (16) | 1 (7) | 31 (14) | 25 (18) | 15 (18) | |