Table 4 Neuropsychiatric assessment
Completion rate of PHQ-9 and GAD-7 scales by timepoint | |||||
PHQ-9 | No. patients required | No. patients completed (% of required) | |||
Baseline | 50 | 49 (98) | |||
Cycle 1 day 15 | 45 | 44 (98) | |||
Cycle 2 day 1 | 40 | 38 (95) | |||
Cycle 2 day 15 | 26 | 26 (100) | |||
Cycle 3 day 1 | 19 | 15 (79) | |||
Off treatment | 50 | 36 (72) | |||
GAD-7 | No. patients required | No. patients completed (% of required) | |||
Baseline | 50 | 49 (98) | |||
Cycle 1 day 15 | 45 | 44 (98) | |||
Cycle 2 day 1 | 40 | 38 (95) | |||
Cycle 2 day 15 | 26 | 26 (100) | |||
Cycle 3 day 1 | 19 | 15 (79) | |||
Off treatment | 50 | 36 (72) | |||
Assessment | |||||
Overall (%) | Normal, n (%) | Grade 1, n (%) | Grade 2, n (%) | Grade 3, n (%) | |
PHQ-9 | |||||
Baseline | 49 | 33 (67) | 14 (29) | 2 (4) | 0 (0) |
Highest grade on study | 50 | 11 (22) | 24 (48) | 11 (22) | 4 (8) |
GAD-7 | |||||
Baseline | 49 | 33 (67) | 14 (29) | 2 (4) | 0 (0) |
Highest grade on study | 50 | 21 (42) | 19 (38) | 8 (16) | 2 (4) |
Change to medications for mood disorder | |||||
Total (n = 50), n (%) | |||||
No | - 45 (90) | ||||
Yes | - 5 (10) | ||||